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Cord, fat or bone marrow: why Stem Cells Colombia chose umbilical cord cells

Mesenchymal stem cells can come from three places. Here is how umbilical cord tissue compares and what lab studies show.

5 min readReviewed with the medical team of Stem Cells Colombia

The 30-second version

  • Mesenchymal stem cells can come from bone marrow, fat or the umbilical cord.
  • Cord cells come from newborn tissue, grow readily in the lab and need no harvest from your body.
  • Lab studies show cord cells are younger, grow readily and have strong immune-calming activity.

Imagine two gardens. One has been through fifty summers, a few droughts and a lot of weather. The other was planted last spring. Both can grow tomatoes, but you know which soil you would bet on.

That, in short, is the thinking behind choosing umbilical cord cells. Here is what the comparison actually looks like.

Where can mesenchymal stem cells come from?

Three main places. Bone marrow, drawn from the hip bone with a needle, and fat, collected with a small liposuction.

And the umbilical cord, specifically its soft inner tissue, called Wharton’s jelly.

All three give cells that meet the scientific definition of mesenchymal stem cells. The differences are in age, how the cells behave, and what it costs you to get them.

Does the age of the cells matter?

Cells from your own marrow or fat are as old as you are, and they have lived through everything you have. Studies generally find that adult mesenchymal cells vary from person to person, depending on age and health.

Wharton’s jelly cells come from newborn tissue. Researchers describe them as a more primitive population that expands faster and further in the lab than adult-derived cells.

What about the collection?

With your own cells, the treatment starts with a procedure on you: a marrow draw from the hip or a liposuction.

Umbilical cords are donated after healthy births, from tissue that would otherwise be discarded. Nothing is taken from you, and nothing is taken from the baby or the mother.

Do they behave differently?

Yes. Reviews comparing sources describe cord cells as more proliferative and with strong immune-calming activity in the lab. A study that tested cells from marrow, fat and Wharton’s jelly side by side found each source had its own signature of signals.

Another study compared cells from different parts of the cord and found Wharton’s jelly cells had high, stable growth, which is helpful when you want a consistent product.

Are donor cells accepted by the body?

Mesenchymal cells carry few of the markers the immune system uses to spot strangers, and Wharton’s jelly cells are described as well tolerated. That is why donor cells can be used without matching, unlike a blood transfusion.

Every cord starts with a Colombian donor chosen through an exhaustive selection process. She and her family are screened to confirm that she is free of viruses, bacteria, infections and disease, and more tests are done after the cord is collected. Every batch the clinic receives comes with a quality certificate and a checklist and release document that lists which tests were done and their results.

Every patient is reviewed by a doctor first, every IV protocol starts with cancer markers for your safety, and you receive a quality certificate for each vial used in your treatment.

So is cord always the right choice?

For patients, the doctors consider it the most practical one: young cells, a consistent source, and nothing taken from you. That is a reasoned choice, and the doctors are open about the reasons.

What matters just as much is what happens next: how the cells are handled, who applies them, and whether they reach the right spot. That is why the specialists apply the cells under imaging guidance, in an operating room.

So when you compare clinics, ask about the source, and then keep asking about the rest.

What this means for you

  1. Ask any clinic which tissue its cells come from and why they chose it.
  2. Remember that no harvest procedure is needed with umbilical cord cells.
  3. Start with a free evaluation, and ask how the cells will reach your problem.
Where the evidence stands

Lab & animal studiesFirst human studiesSeveral clinical trialsStandard of care

Laboratory studies and reviews consistently describe Wharton’s jelly cells as a primitive population that expands well and has strong immune-modulating activity, and show that each tissue source has its own profile. Head-to-head trials in patients are the next step, and research is growing; choosing cord cells is a reasoned choice based on these findings.

  1. Wharton’s jelly-derived cells are a primitive stromal cell population · Stem Cells, 2008
  2. Umbilical cord mesenchymal stem cells: the new gold standard for mesenchymal stem cell-based therapies? · Tissue Engineering Part B: Reviews, 2014
  3. Differential immunomodulation of human mesenchymal stromal cells from various sources in an inflammation mimetic milieu · Cytotherapy, 2022
  4. Mesenchymal Stromal Cells from Different Parts of Umbilical Cord: Approach to Comparison & Characteristics · Stem Cell Reviews and Reports, 2021

Questions

Why not use my own cells?

Using your own cells means a harvest procedure first, and adult cells vary with age and health. Wharton’s jelly cells come from young tissue and need nothing taken from you.

Is it safe to receive donor cells?

Mesenchymal cells are generally well tolerated without matching. Each donor is chosen through an exhaustive selection process and screened with her family for viruses, bacteria, infections and disease, with more tests after the cord is collected. A doctor reviews your case before treatment.

Are umbilical cord cells proven to work better?

Lab studies favor them in several ways, and research in patients is growing. Stem Cells Colombia chose them for their youth, consistency and the fact that nothing is taken from you.

Is stem cell therapy approved by the FDA?

Stem cell therapy is not approved by the FDA, but in Colombia it is legal.


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