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Shoulder science

Rotator cuff injuries: why they heal slowly, and what stem cell studies show

Why rotator cuff tendons heal slowly, which tears may be treated without surgery, and what studies of stem cells in the shoulder have found.

6 min readReviewed with the medical team of Stem Cells Colombia

The 30-second version

  • The rotator cuff is four small muscles whose tendons hold your shoulder ball in its socket.
  • Many partial and degenerative tears are treated without surgery, and a specialist reads your MRI to plan yours.
  • Stem cell studies in the rotator cuff are encouraging, with a good safety record.

Reaching for the top shelf, putting on a jacket, sleeping on that side: if your shoulder complains at every one of these, the rotator cuff is the usual suspect.

Maybe a surgeon has already mentioned an operation, and a few months in a sling. Before you decide anything, here is what the rotator cuff is, why it heals so slowly, and what stem cells may offer you.

What is the rotator cuff, and why does it tear?

It is a group of four small muscles whose tendons wrap around the top of your arm bone. Their job is to keep the ball of the shoulder centered in a very shallow socket while bigger muscles do the heavy lifting.

Imagine a golf ball sitting on a tee, held in place by four thin straps. That arrangement gives the shoulder its huge range of motion, and it is also why those straps take a beating.

Tears come from a fall or a sudden pull, but more often from years of wear. After 50, some degree of fraying is common, even in people with no pain at all.

Why does a rotator cuff tendon heal so slowly?

Tendons have a poor blood supply, especially near where they attach to bone, which is exactly where the cuff usually tears. Less blood means fewer repair cells and slower healing.

That is why surgeons and researchers have spent years looking for ways to help the tissue heal better.

Which tears can be treated without surgery?

Many partial and degenerative tears, and tendinopathy, the tendon being irritated and worn without a clear tear, are treated without surgery. Physical therapy is the foundation.

Cortisone shots aim at the pain signal. People with a stubborn partial tear often look for options that aim at the tissue itself.

For a full-thickness tear with the tendon pulled back from the bone, your specialist checks whether surgery should come first. An MRI usually tells the two apart, so your plan is designed for you.

What would stem cells do in the shoulder?

Mesenchymal stem cells, or MSCs, act mainly as messengers. Placed at the injured tendon under ultrasound, they release signals that may calm inflammation and support the tendon’s own repair.

The stem cells used at Stem Cells Colombia come from the Wharton’s jelly of donated umbilical cords, so nothing is harvested from your body.

What do the studies show?

A 2023 systematic review of umbilical cord tissue and cord MSCs for rotator cuff injuries found them safe and potentially helpful, and called for larger randomized trials.

In a first-in-human study of partial tears, injections of MSCs from patients’ own fat improved pain and function and reduced the size of the defect on MRI.

In short: research is growing, the cells have been safe in the studies so far, and the results are promising.

What this means for you

  1. Find out whether your tear is partial or full-thickness before choosing any treatment.
  2. If it is partial or degenerative, ask for a free evaluation of a non-surgical option.
  3. Keep your physical therapy; any cell treatment is meant to support it, not replace it.
Where the evidence stands

Lab & animal studiesFirst human studiesSeveral clinical trialsStandard of care

Research on stem cells in rotator cuff injuries is growing. A systematic review of umbilical cord tissue and cord MSCs reported a good safety record and possible benefit, and a first-in-human study with fat-derived MSCs showed improvement in partial tears. Larger trials are building on these results to show which tears respond best.

  1. Allogenic umbilical cord tissue for rotator cuff injuries · Sports Medicine and Arthroscopy Review, 2023
  2. Intratendinous injection of autologous adipose tissue-derived mesenchymal stem cells for the treatment of rotator cuff disease: a first-in-human trial · Stem Cells, 2018

Questions

Can stem cells help a torn rotator cuff heal without surgery?

Many partial and degenerative tears are treated without surgery, and stem cells are studied to support that healing. A specialist reviews your MRI to see whether your tear is a good fit.

What if my tear is complete?

Your specialist reviews your MRI first. A full-thickness tear with the tendon pulled back often starts with a surgeon, and the specialist tells you clearly which path fits you.

When could I notice a change?

Every body responds at its own pace; improvement builds gradually and is usually expected at four to six months.

Is stem cell therapy approved by the FDA?

Stem cell therapy is not approved by the FDA, but in Colombia it is legal.


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